I was talking to a friend today who loves all things gut-related, including poo.
He’s highly educated, very smart, and on top of the news.
“Microbiome,” he laughed. “I’m a gut guy but I had to look it up. I still don’t really know what it is. That word confuses me. What’s the microbiome?”
So What’s the Microbiome?
We think of ourselves as humans.
We believe we are a distinct, highly intelligent species apart from other animals.
And as humans, we value cleanliness and hygiene.
We think of non-human microorganisms as unintelligent, unclean, and unsafe.
We do everything we can to stop them:
✅ Antibacterial soap
✅ Antibiotics for infections
✅ Antibacterial hand sanitizer
We want to stop the microbes because—in this old-school worldview—microbes are bad.
“Germs make us sick.”
Except none of that is correct.
We’re walking colonies of many different species, including something like 37 trillion bacteria as well as fungi, protists, and viruses.
These microorganisms live on our skin, in our mouths, in our reproductive organs, in our guts, and elsewhere.
Voilà the answer to the question what’s the microbiome?:
The microbiome is the non-human microscopic life that lives in us and on us.
Our bodies’ microscopic cohabitators aren’t just freeloaders.
These microscopic organisms help us with digestion, circulation, healthy immune responses to diseases, detoxification, and possibly much more.
So Why Does the Microbiome Matter?
New science about the microbiome and its role in human health and human disease is emerging all the time.
In one small but fascinating study of 19 healthy volunteers, scientists found that people who use anti-bacterial mouthwash had increased high blood pressure.
The team of researchers at Queen Mary University in London hypothesized that antiseptic mouthwash may kill beneficial bacteria that help the blood vessels relax.
Our data further suggest that disturbances in nitrite homeostasis (herein achieved via interruption of nitrate reduction in the oral cavity by commercial mouthwash use) have small, yet potentially important, implications for cardiovascular health.
Apart from vasodilator actions, nitrite-derived nitric oxide has a number of other potentially beneficial effects in humans, including inhibition of platelet aggregation, preservation of endothelial function, and improvement of mitochondrial efficiency.
In other words, while some “germs” may make us sick (a slogan that was popular in the 1970s when I was growing up), other “germs” may help keep us well.
In another study, scientists found that if you give lab animals antibiotics when they’re fighting a viral infection you can severely compromise their immune systems and make it much more likely that they will die of the viral infections.
Is the One Germ Causes One Disease Model Out of Date?
The answer to the question “What’s the microbiome?” gets more nuanced as we discover more about the microbes living in us and on us.
Though the concept of the microbiome has been around for more than a decade, scientists are just beginning to understand the beneficial role bacteria and other organisms play in human health.
Writing this month in Trends in Ecology & Evolution, a team of five scientists from the University of Exeter and The Centre for Environment, Fisheries and Aquaculture Science (Cefas) posit that our understanding of how humans get sick must fundamentally change based on our understanding of how the microbiome helps keep us well.
Read the highlights here.
The one pathogen one disease model, these scientists argue, may be an outdated and inaccurate concept.
Instead of believing that one “germ” causes one disease, it may be that diseases are caused by a “pathobiome,” a complicated interaction between microbes and their hosts that leads to disease in plants, animals, and humans.
Does your head hurt from all these new ideas?
Now that you know what the microbiome is, what’s the take-away?
Channel your inner evolutionary biologist (aka be like my mom, Lynn Margulis) and embrace the microbial world.
They’ve been around longer than we have.
They may well be smarter than we are.
They’re small but they’re mighty.
And they’re helping us humans survive and thrive.
What’s the Microbiome? Related articles:
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